Ceftazidime Pharmacokinetic in Cerebrospinal Fluid Between Continuous and Intermittent Administration
Status:
Unknown status
Trial end date:
2009-06-01
Target enrollment:
Participant gender:
Summary
Meningitis is an infection where morbidity and mortality depend on the delay of the initial
treatment for a good prognostic. The antibiotherapy rapidity allows to decrease the
mortality. Intermittent administration of ceftazidime is a reference treatment of Pseudomonas
aeruginosa meningitis. In the case of Pseudomonas aeruginosa pneumopathy, ceftazidime can be
administered by intermittent injections or by continuous perfusion. The continuous
administration of ceftazidime is not validated in Pseudomonas aeruginosa meningitis. However,
ceftazidime is a time dependant antibiotic and continuous treatment would provide a more
efficient therapeutic. The aim of this study is to determine if the continuous administration
of ceftazidime could permit a better therapeutic practice of Pseudomonas aeruginosa
meningitis compared with intermittent administrations.