Cediranib, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma
Status:
Completed
Trial end date:
2014-04-01
Target enrollment:
Participant gender:
Summary
This phase I/II trial is studying the side effects and best dose of cediranib to see how well
it works when given together with temozolomide and radiation therapy in treating patients
with newly diagnosed glioblastoma. Cediranib may stop the growth of tumor cells by blocking
some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Drugs
used in chemotherapy, such as temozolomide, work in different ways to stop the growth of
tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy
uses high-energy x-rays to kill tumor cells. Giving cediranib together with temozolomide and
radiation therapy may kill more tumor cells.