Caudal Versus Intravenous Magnesium Sulfate on Emergence Agitation After Sevoflurane In Children.
Status:
Unknown status
Trial end date:
2019-08-01
Target enrollment:
Participant gender:
Summary
Sevoflurane is the agent of choice for induction and maintenance of day care anesthesia in
children and has a wide acceptance among pediatric anesthesiologists.
Emergence agitation (EA) is a frequent postoperative complication in pediatric patients
receiving inhalational anesthetics with a rapid recovery, e.g. sevoflurane Magnesium sulfate
is a non anesthetic N-methyl-D-aspartate receptor antagonist, Regional anesthetic techniques
have major two benefits which are lowering anesthetic requirements intraoperatively and
providing adequate postoperative pain relief.
Magnesium sulfate is an adjuvant that alters the perception and duration of pain by serving
as an antagonist of N-methyl-D-aspartate glutamate receptors. Caudal injection of bupivacaine
with magnesium sulfate in pediatric patients after inguinoscrotal operations provided
adequate postoperative analgesia without producing many side effects. Caudal block with local
anesthetic with or without adjuvants may prevent emergence agitation with effective
postoperative pain management.
- So the aim of this study is to compare the efficacy of caudal versus intravenous
magnesium sulfate infusions in controlling emergence agitations after inhalational
sevoflurane anesthesia in children who will undergo lower abdominal surgeries.
Participants and methods
All participants will receive caudal block with bupivacaine 0.25% 1mg/kg dialed in 10 cm
saline.
The participants will be divided to 3 groups
1. Bupivacaine group (B group) (group 1) N = 31 :-
2. Magnesium sulfate caudal group (MC group) (group 2) N = 31 :-
3. Magnesium sulfate I.V group (MV group) (group 3) N = 31 :-
Postoperative assessment in the ( PACU):-
- The oxygen saturation (SO2), heart rate (HR), and mean arterial pressure (MAP) are
monitored by the observer blinded to group allocation on admission and 10 mins till
discharge (0, 10, 20, 30, 40, 50, 60mints, time of discharge) from the PACU.
- Emergence agitations (Pediatric anesthesia emergency delirium scale (PAED) The presence
of Emergence agitation and its severity will be measured using (PAED).
The presence of Pain and its severity will be measured using FLACC scale.
- Time of first postoperative administration of fentanyl in mints
- Modified Aldrete score :- The discharge from the PACU will be measured using Modified
Aldrete score.
Phase:
N/A
Details
Lead Sponsor:
Mansoura University
Treatments:
Anesthetics Anesthetics, Local Bupivacaine Magnesium Sulfate N-Methylaspartate Sevoflurane