Catheter Directed Interventions in Pulmonary Embolism

• Status: Unknown status
• Trial end date: 2021-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Evaluating the safety and outcomes of catheter directed thrombolysis following catheter fragmentation in acute high risk pulmonary embolism

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assiut University
• Treatments: Streptokinase

Criteria

Inclusion Criteria:

• Patients with angiographically confirmed acute high risk pulmonary embolism with shock index >1.

• Pulmonary arterial occlusion with >50% involvement of the central (main and/or lobar) pulmonary , and pulmonary hypertension (mean pulmonary artery pressure >25 mmHg)

• Patients with high risk pulmonary embolism who remain unstable after receiving fibrinolysis

• Patients with high risk pulmonary embolism who cannot receive fibrinolysis

• Patients with acute intermediate-high risk pulmonary embolism with adverse prognosis (new hemodynamic instability, worsening respiratory failure, severe RV dysfunction, or major myocardial necrosis)

Exclusion Criteria:

• Patients with echocardiographically confirmed right sided thrombi.

• Patients with low-risk pulmonary embolism or intermediater-low risk acute pulmonary embolism with minor RV dysfunction, minor myocardial necrosis, and no clinical worsening

• Acute gastrointestinal bleeding.

• Anticoagulation with international normalized ratio >1.8 or severe coagulopathy.

• Anaphylactic reaction to contrast media.

• Acute stroke.

• Acute renal failure or severe chronic non-dialysis dependent kidney disease.

• Uncooperative patient