Catheter Ablation Versus Medical Treatment of AF in Heart Failure

• Status: Unknown status
• Trial end date: 2011-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Heart failure and atrial fibrillation (AF) often coexist, and each increases the morbidity and mortality associated with the other. The investigators hypothesized that restoration of normal sinus rhythm by catheter ablation is superior to medical treatment of AF in heart failure. This study randomizes patients with heart failure and persistent AF to medical treatment of AF or catheter ablation to restore sinus rhythm.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Barts & The London NHS Trust
• Collaborator: British Heart Foundation
• Treatments: Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Enzyme Inhibitors; Mineralocorticoid Receptor Antagonists

Criteria

Inclusion Criteria:

• Persistent atrial fibrillation

• Symptomatic heart failure

Exclusion Criteria:

• Reversible causes of heart failure

• Contraindications to catheter ablation