Carvedilol Vascular Efficacy Trial

• Status: Completed
• Trial end date: 2011-11-01
• Target enrollment: 0
• Participant gender: All

Summary

Beta-blockers should be administered to all patients with heart failure stages II to IV NYHA. It should also be administered to patients with stage I after myocardial infarction. The low ejection fraction, especially after myocardial infarction is a strong indication for beta-blockers, as many studies indicate that administration of these drugs substantially reduces cardiovascular mortality. Beta-blockers reduce mortality and hospitalizations and improve the operational phase for all categories of patients with heart failure. Since beta-blockers, only carvedilol, metoprolol, and recently visoprololi nevimpololi have shown these benefits and thus, only those have to be administered.

The clinical study Carvedia aims to observe and record the action of beta-blocker carvedilol on cardiac function in patients with heart failure or reduced left ventricular ejection fraction after acute myocardial infarction.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Elpen Pharmaceutical Co. Inc.
• Treatments: Carvedilol

Criteria

Inclusion Criteria:

1. Patients visiting outpatient clinics.

2. Male or female patients over 18 years

3. Patients with mild heart failure and history of symptoms according to the instructions of the European Society of Cardiology (ESC)

4. Patients who entered the study have LVEF <40% in echocardiography

5. Patients with new diagnosis of heart failure

6. Patients who have left ventricular ejection fraction after acute myocardial infarction <40%

7. Patients who have been treated in hospital during the previous month before their inclusion in the study

8. Patients who have signed the consent form for recording and processing of personal data.

9. Patients who are willing to comply with the requirements of the study

10. Patients who are treated with carvedilol for at least a month before their inclusion in this

Exclusion Criteria:

1. Patients under 18 years

2. Patients with unstable chronic heart failure

3. Patients with unstable hemodynamic profiles

4. Patients with heart valve disease

5. Patients with hypertrophic cardiomyopathy

6. Patients with unstable angina or active myocarditis

7. Patients with contraindications to treatment with beta-adrenergic receptors

8. Patients who have not consented to recording and processing of personal the data.

9. Women pregnant or breastfeeding

10. Patients have been treated in hospital during the preceding months before their inclusion in the study

11. Patients treated with carvedilol for less than one month