Carotid Plaque Characteristics by MRI in AIM-HIGH (Carotid MRI Substudy)

• Status: Completed
• Trial end date: 2015-02-01
• Target enrollment: 0
• Participant gender: All

Summary

Heart attacks and strokes caused by the unstable atherosclerotic plaques remain the leading cause of death in the United States. Unstable plaques often have more fat than stable plaques. This study will investigate if a treatment with LDL-lowering plus HDL-raising compared with LDL-lowering alone would more effectively reduce the plaque fat content assessed by magnetic resonance imaging (MRI), therefore, further reducing heart attacks and strokes.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Washington
• Collaborator: National Heart, Lung, and Blood Institute (NHLBI)
• Treatments: Niacin; Niacinamide; Nicotinic Acids; Simvastatin

Criteria

Inclusion Criteria:

• Eligible for main AIM-HIGH study (NCT00120289)

• Medically able to undergo MRI procedure

• Willing to provide informed consent for participation in this substudy

Exclusion Criteria:

• Uses pacemaker or has metallic implants

• History of bilateral carotid endarterectomy

• Glomerular filtration rate less than 60 mL/min/1.73 m^2