Carotid Intima-media Thickness in Japan Statin Treatment Against Recurrent Stroke(J-STARS Echo)

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Carotid ultrasound can reveal the intima-media complex thickness(IMT), that has been reported to be a marker of atherosclerosis as well as a risk of cardiovascular events, and to be attenuated by 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) . This substudy of J-STARS will observe the temporal profile of carotid IMT prospectively in the patients with prescription of pravastatin and the control.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan; Translational Research Informatics Center, Kobe, Hyogo, Japan
• Collaborators: Hiroshima University; Ministry of Health, Labour and Welfare, Japan; National Cerebral and Cardiovascular Center
• Treatments: Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pravastatin

Criteria

Inclusion Criteria:

• Ischemic stroke except for cardiogenic embolism, from 1 month to 3 years after onset

• Hyperlipidemia and total cholesterol level of 180-240mg/dl without the prescription of statin within previous 30 days

• Able to visit outpatient department

• Informed consent on the form.

Exclusion Criteria:

• Ischemic stroke of other determined cause according to the TOAST classification

• Ischemic heart disease and necessary to use statin

• Hemorrhagic disorders

• Platelet count <=100,000/ul within 3 months prior to study start

• Alanine aminotransferase (ALT) or aspartate aminotransferase (AST)>= 100IU/L within 3 months prior to study start

• Serum creatinine >=2.0mg/dl within 3 months prior to study start

• A scheduled operation

• The presence of malignant disorder

• Patients whom carotid ultrasound cannot examine because of neck tumor or torticollis

• Patients after carotid endarterectomy or radiation therapy to neck

• Patients whose carotid ultrasound cannot be examined because of neck tumor or torticollis

• Patients after carotid endarterectomy or radiation therapy to neck