Carmustine Implants and O(6)-Benzylguanine in Treating Children With Recurrent Malignant Glioma
Status:
Terminated
Trial end date:
2004-07-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die. Chemotherapy placed into the surrounding tissue after surgery to
remove the tumor may kill any remaining tumor cells. O(6)-benzylguanine may increase the
effectiveness of carmustine by making tumor cells more sensitive to the drug.
PURPOSE: Phase I trial to study the safety of combining O(6)-benzylguanine with carmustine
implants in treating children who have recurrent malignant glioma.