Cariprazine Effects on Brain and Behavior in Cocaine Use Disorder
Status:
Terminated
Trial end date:
2020-09-04
Target enrollment:
Participant gender:
Summary
This is a phase II, randomized, single-blind, placebo-controlled study to examine whether
cariprazine (1.5 or 3 mg/d) 1) alters brain and/or behavioral responses to probes of reward
and inhibition and 2) decreases cocaine use in individuals with cocaine use disorder.
Subjects will be tested as inpatients during fMRI sessions. After the 2-week
inpatient/medication induction phase, study medication will continue for 8 outpatient weeks,
during which time cocaine use will be tracked. Subjects will be monitored during a 4-wk
followup phase thereafter.