The objectives of the study are to explore the effect of treatment with tiotropium +
olodaterol fixed dose combination (FDC) compared to fluticasone propionate + salmeterol FDC
on:
- reversal of left ventricular diastolic dysfunction assessed with cardiac magnetic
resonance (CMR) imaging,
- measures of arterial stiffness assessed by CMR and pulse wave analysis (PWA),
- reduction of hyperinflation assessed with body plethysmography and
- post dose spirometry.