Cardiovascular Effects of Racemic Epinephrine Pellets
Status:
Completed
Trial end date:
2019-11-30
Target enrollment:
Participant gender:
Summary
The primary aim of this study was to determine if topical racemic epinephrine pellets affect
heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) or mean
arterial pressure (MAP) in children receiving dental care under general anesthesia (GA).
Thirteen patients requiring prefabricated zirconia crowns on both primary maxillary first
molars were recruited into a split-mouth randomized controlled pilot study. Patients received
a continuous infusion of propofol and remifentanil with inhaled nitrous oxide/oxygen. After
patient randomization and tooth preparation, either saline pellets (control) or racemic
epinephrine pellets (treatment) were applied directly to gingival tissue. Vital sign
measurements were recorded for 5 minutes. The procedure was repeated with either control or
treatment on the contralateral side.