Cardiovascular Effects of Chronic Sildenafil in Men With Type 2 Diabetes
Status:
Completed
Trial end date:
2009-12-01
Target enrollment:
Participant gender:
Summary
Type 2 Diabetes Mellitus (T2DM) represents a model of endothelial dysfunction, where chronic
nitric oxide deprivation, hyperglycaemia and hyperinsulinemia and fibrogenic mediators lead
to cardiovascular remodelling associated with diabetic cardiomyopathy and in consequence to
secondary complications of diabetes. Specific anti-oxidative and anti-fibrotic therapies are
not currently available. Sildenafil (Viagra) has demonstrated the capability of significantly
improving endothelial dysfunction and cardiac fibrosis in experimental animal models.
The purpose of the present study is performed to establish the effect of chronic high dose
sildenafil treatment on heart performance in diabetic subjects.