Cardioprotective Effect of Ketamine-dexmeditomidine Versus Fentanyl-midazolam in Open Heart Surgery in Pediatrics
Status:
Recruiting
Trial end date:
2022-09-25
Target enrollment:
Participant gender:
Summary
congenital hearts are very sensitive and irritable to deal with, especially during repair
defects, the child's heart is exposed to impaired myocardial function during the entire
procedure. Moreover, reperfusion of the heart during open-heart surgery when the myocardium
is exposed to a global ischaemic cardioplegic arrest can induce myocardial injury. Myocardial
reperfusion injury activates neutrophils, which trigger an inflammatory response resulting in
the generation of reactive oxygen species (ROS), cytokine release, and complement activation,
which further induce more cardiac injury. In addition to the inflammatory response generated
as a result of tissue reperfusion injury, there is a significant systemic inflammatory
response that is triggered by cardiopulmonary bypass (CPB) during open-heart surgery