Cardiac Sympathetic Denervation for Prevention of Ventricular Tachyarrhythmias
Status:
Recruiting
Trial end date:
2023-08-31
Target enrollment:
Participant gender:
Summary
The purpose of this research study is to examine the effect of cardiac sympathetic
denervation (CSD) surgery on life threatening abnormal heart rhythms called ventricular
tachycardia or ventricular fibrillation that can lead to sudden cardiac death. Subjects will
be asked to participate in this research study if they have recurrent ventricular tachycardia
(at least one ICD shock for ventricular tachycardia) and have undergone at least one catheter
ablation procedure or have ventricular tachycardia or fibrillation that is not ablatable. The
goal of this study is to determine whether cardiac sympathetic denervation can prevent these
abnormal heart rhythms from occurring and therefore, prevent, ICD shocks which are not only
painful, but have been shown to reduce quality of life and/or lead to depression,
particularly in the period immediately after the shock.
Phase:
Phase 3
Details
Lead Sponsor:
University of California, Los Angeles
Collaborators:
Johns Hopkins University Mayo Clinic Minneapolis Veterans Affairs Medical Center University of Alabama at Birmingham Vanderbilt University Washington University School of Medicine