Cardiac Index Changes With Ephedrine, Phenylephrine, Ondansetron and Norepinephrine During Spinal Anesthesia

• Status: Completed
• Trial end date: 2018-03-30
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of the study is to evaluate the cardiac output changes after an intravenous bolus of ephedrine, phenylephrine, ondansetron or norepinephrine during a spinal anesthetic for a cesarean delivery.

For elective cesarean delivery, all participants will receive spinal anesthesia with a local anesthetic and sufentanil. This study includes 120 pregnant women. Patients will be randomly assigned according to a computer generated system to be in one of four groups.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University Tunis El Manar
• Treatments: Anesthetics; Benzocaine; Ephedrine; Epinephrine; Epinephryl borate; Norepinephrine; Ondansetron; Oxymetazoline; Phenylephrine; Pseudoephedrine; Racepinephrine

Criteria

Inclusion Criteria:

• ASA I / II

• Caesarean section, non-twinned

Exclusion Criteria:

• heart disease

• HTA

• non-gestational diabetes

• pre-eclampsia

• sepsis

• BMI greater than 40

• contraindication to spinal anesthesia: patient refusal, medicinal allergy, long QT syndrome.