Carbetocin vs. Oxytocin: In-vitro Myometrial Contractions With and Without Oxytocin Pre-treatment
Status:
Completed
Trial end date:
2012-08-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to compare the ability of an isolated sample of uterine muscle
tissue (in a tissue bath) to contract in the presence of various drugs. The drugs
studied--uterotonics--are typically used to contract the uterus when a pregnant patient
continues to bleed after delivery. Oxytocin is an old standard, but seems to suffer from a
desensitization phenomenon. Carbetocin, a similar drug, has recently been suggested to
clinicians as a replacement for oxytocin directly after certain types of Cesarean section.
The investigators will be testing isolated uterine muscle samples after pre-treatment with
oxytocin OR nothing (control) to increasing concentrations of oxytocin OR carbetocin.
Contractile measures will be measured and compared between all groups. The investigators
hypothesize that oxytocin pre-treatment will reduce contractions in both oxytocin- and
carbetocin-induced contractions, and oxytocin and carbetocin will induce different patterns
of contractions.
Phase:
N/A
Details
Lead Sponsor:
Samuel Lunenfeld Research Institute, Mount Sinai Hospital