Capsaicin for Cerebral Perfusion Augmentation

• Status: Not yet recruiting
• Trial end date: 2023-02-01
• Target enrollment: 0
• Participant gender: All

Summary

To determine the effect of capsaicin upon serial transcranial Doppler (TCD) markers of cerebral blood flow (CBF). Methods Serial TCD testing in 30 participants with cerebrovascular risk factors. Capsaicin doses .66 and .99 μMol. Outcomes: peak systolic and end-diastolic velocities in the middle cerebral artery (MCA), mean velocity (MV), pulsatility index (PI), CBF index, arterial pressure, and perceived pungency (PP) in five minutes intervals up to 20 minutes.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Instituto Mexicano del Seguro Social
• Collaborator: Centenario Hospital Miguel Hidalgo
• Treatments: Capsaicin

Criteria

Inclusion Criteria:

• Signed Informed Consent Form

• Previous diagnosis and stable condition of one of the following:

Diabetes Mellitus Hypertension Dyslipidemia Chronic Obstructive Pulmonary Disease

Exclusion Criteria:

• History of alergy or hypersensibility to dietary capsaicin

• Previous diagnosis of stroke

• Chronic use of cholinergic/anticholinergic drugs

• Chronic use of sympathomimetic drugs

• Chronic use of serotonergic drugs

• Chronic use of dopaminergic drugs