Capsaicin for Cerebral Perfusion Augmentation.

• Status: Completed
• Trial end date: 2020-07-31
• Target enrollment: 0
• Participant gender: All

Summary

To determine the safety and effect of crescent doses of capsaicin upon serial transcranial Doppler (TCD) markers of cerebral blood flow (CBF). Methods We performed serial TCD testing in 30 healthy volunteers divided into five equal groups. Capsaicin doses ranged from 33 to 165 μMol. We recorded peak systolic and end-diastolic velocities in the middle cerebral artery (MCA), arterial pressure, and perceived pungency (PP) in five minutes intervals up to 20 minutes. We then calculated the mean velocity (MV), the pulsatility index (PI), and the CBF index.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Juan Manuel Marquez Romero
• Collaborators: Centenario Hospital Miguel Hidalgo; Universidad de Guanajuato
• Treatments: Capsaicin

Criteria

Inclusion Criteria:

• Those willing to participate with signed the informed consent form (ICF)

• No diagnosis of any chronic or acute disorder

Exclusion Criteria:

• Eating or drinking at least one h before the measurements

• Eating spicy food for one day before testing.

• Hypertension

• Smoking

• Any disorder of the oral cavity