To determine the safety and effect of crescent doses of capsaicin upon serial transcranial
Doppler (TCD) markers of cerebral blood flow (CBF). Methods We performed serial TCD testing
in 30 healthy volunteers divided into five equal groups. Capsaicin doses ranged from 33 to
165 μMol. We recorded peak systolic and end-diastolic velocities in the middle cerebral
artery (MCA), arterial pressure, and perceived pungency (PP) in five minutes intervals up to
20 minutes. We then calculated the mean velocity (MV), the pulsatility index (PI), and the
CBF index.
Phase:
Phase 1
Details
Lead Sponsor:
Juan Manuel Marquez Romero
Collaborators:
Centenario Hospital Miguel Hidalgo Universidad de Guanajuato