Capsaicin Effect on Cytokines Profile in Dyslipidemia
Status:
Unknown status
Trial end date:
2017-10-01
Target enrollment:
Participant gender:
Summary
The increased mortality from cardiovascular disease has a significant impact on the
population, and the prevalence of these diseases it become one of the major problems, since
it is the leading cause of mortality and 1 in 3 Mexicans suffer from cardiovascular disease
according ENSANUT; the above is attributed to the increase of diseases associated with an
inflammatory process accelerated as obesity, dyslipidemia, hypertension (SAH) and diabetes
mellitus (DM).
The cholesterol is a major risk factor in the development of cardiovascular disease, and in
turn increases the chances of death; however, the treatment of choice is based on changes in
lifestyle, which for most people are difficult to maintain long-term. As for the drug therapy
treated with drugs many people do not achieve their therapeutic goals, and therefore the
inflammatory condition that underlies this disease remains.
Recent studies have focused on the possible role of capsaicin in the inflammatory state
through the agonistic effect it has on TRPV1. It has demonstrated the antiinflammatory
activity of capsaicin to enhance inflammation by free fatty acids (FFA) and reducing the
expression of certain genes involved in this process induced. Capsaicin is a natural choice
and well tolerated with few side effects limited to the gastrointestinal tract such as
dyspepsia and intestinal irregularity, for the above is of interest to evaluate the effect of
capsaicin on the profile of inflammatory cytokines in individuals with dyslipidemia.