The primary objective of the proposed study is to evaluate the safety and efficacy of Caplyta
(lumateperone) in adults with borderline personality disorder (BPD). Sixty subjects with BPD
will be randomized in a 1:1 fashion to either Caplyta (42mg/day) or matching placebo for 8
weeks of active treatment. The hypothesis to be tested is that Caplyta will result in greater
rates of reduction in symptoms of BPD compared to placebo (improvement in symptoms will be
indicated by lower scores on established outcome measures of BPD symptoms that have been used
in prior studies).