Overview

Cantharidin-induced Skin Blister for Testing Anti-inflammatory Effects of Macrolides

Status:
Completed
Trial end date:
2009-11-27
Target enrollment:
0
Participant gender:
Male
Summary
The purpose of this study is to investigate the utility of the cantharidin-induced skin blister assay for evaluation of the anti-inflammatory effects of macrolides in healthy male volunteers.
Phase:
Phase 1
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
GlaxoSmithKline
Treatments:
Anti-Inflammatory Agents
Azithromycin
Cantharidin
Criteria
Inclusion Criteria:

- Healthy as determined by a responsible and experienced physician.

- Male between 18 and 65 years of age inclusive, at the time of signing the informed
consent.

- The subject has a body weight of more than or equal to 50 kg and a BMI 18.5 to 30
kg/m2.

- Capable of giving written informed consent, which includes compliance with the
requirements and restrictions listed in the consent form.

Exclusion Criteria:

- Subjects with very fair skin type.

- Presence on either forearm of tattoos, naevi, scars, keloids, hyperpigmentation,
excessive hair or any skin abnormalities that may, in the opinion of the investigator,
interfere with study assessments.

- Subjects with a history of keloids, skin allergy, hypersensitivity or contact
dermatitis, including previous reactions to dressings to be used in the study.

- Subjects with a history of lymphangitis and/or lymphoedema.

- Subjects with a history of HIV infection, hepatitis B or C.

- A positive pre-study drug/alcohol screen.

- Use of prescription or non-prescription drugs, including ergot derivatives e.g.
dihydroergotamine (Dihydergot), vitamins, herbal and dietary supplements (including St
John's Wort) within whichever is the longer period of 14 days or 5 half-lives (if
known) prior to the first challenge day, unless in the opinion of the Investigator and
GSK Medical Monitor the medication will not interfere with the study procedures or
compromise subject safety.

- The subject has participated in a clinical trial and has received an investigational
product within the following time period prior to the dosing day in the current study:
90 days, 5 half-lives or twice the duration of the biological effect of the
investigational product (whichever is longer).

- Where participation in the study would result in donation of blood or blood products
in excess of 500 mL within 56-day period.

For part C only:

- QTcB or QTcF >450 msec, based on average QTc value of triplicate ECGs obtained over a
brief recording period, if the first measurement shows abnormal QTc value.

- History of sensitivity to azithromycin, macrolide/ketolide antibiotics or components
thereof or a history of drug or other allergy that, in the opinion of the investigator
or GSK Medical Monitor, contraindicates their participation.