Cannabis Inhalation: Effects on Cardiovascular Function During Rest and Exercise
Status:
Not yet recruiting
Trial end date:
2022-09-01
Target enrollment:
Participant gender:
Summary
This two-phase project seeks to examine the cardiovascular response to consumption of
cannabis variants of different cannabinoid composition through different methods (smoking vs.
vaporizing), at rest and during aerobic exercise. Multiple measures that have been shown to
predict risk factors for chronic-disease and negative health outcomes will be assessed
following cannabis consumption at rest or in combination with exercise. These techniques will
examine arterial stiffness, vascular function, and cardiac function. In phase I and II,
subjects will visit the lab on 6 different occasions; with 1 visit acting as an introductory
visit, 1 as an exercise control visit, 2 as resting cannabis visits, and 2 as cannabis +
exercise visits. Cannabis used in phase I of this study will consist of approximately 10%
THC. On all visits, pulse wave velocity, flow mediated dilation, and echocardiography
measures will be performed following cannabis consumption by smoking or vaporizing, and
cannabis consumption by smoking or vaporizing followed by 20 minutes of exercise on a cycle
ergometer. Phase II of the study will implore a similar design. In favor of altering method
of consumption, in all visits cannabis will be consumed by vaporization and will be either a
high cannabidiol (CBD: (~10%)) and low delta-9-tetrahydrocannabinol (THC: (<1%)), or a high
THC (~10%) and low CBD (<1%) variant.