Cannabinoid Control of Fear Extinction Neural Circuits in Humans
Status:
Completed
Trial end date:
2014-07-01
Target enrollment:
Participant gender:
Summary
The goal of the current proposal is to investigate the effects of a cannabinoid drug on the
memory of extinguished fear in humans and the brain circuitry important for the recall of
extinction learning. The investigators findings will translate previous discoveries from
animal studies to humans and increase their understanding of the neurobiological mechanisms
supporting retention of extinction memory. This proof-of-concept study is a critical
translational first step towards the development of cannabinoid modulators as an adjunctive
strategy to exposure-based therapies to augment extinction learning and prevent the return of
fear memories in patients with post-traumatic stress and other anxiety disorders.
Phase:
Phase 4
Details
Lead Sponsor:
University of Illinois at Chicago
Collaborators:
National Institute of Mental Health (NIMH) National Institutes of Health (NIH)