Cannabidiol (CBD) is one of 700 chemicals derived from the Cannabis sativa plant and is both
legal and widespread for distribution in the state of Vermont. The central hypothesis of this
proposal is that in apparently healthy adults, acute CBD favorably affects the autonomic
nervous system and that this will be evident by an increase in heart rate variability. The
overall goal is to understand how CBD affects the autonomic and cardiovascular systems at
rest, and when perturbed. The investigators will study a narrow age range of adults,
administer varying acute doses of CBD, characterize baseline cardiovascular variables, and
record responses to autonomic challenge maneuvers. This will provide the framework to assess
potential therapies and/or risk factors of CBD, particularly as it relates to healthy
individuals. More information that is so widely taken, especially one that targets receptors
known to be involved in cardiovascular signaling pathways is imperative.