Overview

Cancer and Anesthesia: Survival After Radical Surgery - a Comparison Between Propofol or Sevoflurane Anesthesia

Status:
Recruiting
Trial end date:
2022-09-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to determine whether anesthesia maintained with propofol results in better one- and five-year-survival than anesthesia maintained with sevoflurane.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Uppsala University
Collaborators:
Air Force Military Medical University, China
Helsingborgs Hospital
Kalmar County Hospital
Karlstad Central Hospital
Lund University Hospital
Peking University First Hospital
Region Örebro County
Renji Hospital, Shanghai
Skellefteå lasarett
Sundsvall Hospital
University Hospital "Sestre Milosrdnice"
University Hospital, Linkoeping
Uppsala University Hospital
Växjö Hospital
Wroclaw Medical University
Treatments:
Anesthetics
Propofol
Sevoflurane
Criteria
Inclusion Criteria:

- Be informed of the nature of the study and have provided written informed consent

- At least 18 years of age

- Patient that is scheduled for elective radical breast- or colorectal cancer surgery in
general anesthesia. Radical surgery means that the aim of the surgery is to cure
(adjuvant treatment such as chemotherapy and/or radiation therapy seen as part of the
curative treatment).

Exclusion Criteria:

- The surgery that is going to be made is an acute surgical procedure

- The surgery that is going to be made is palliative surgery

- Known or suspected hypersensitivity to either propofol or sevoflurane or presence of
any contraindication according to the substances' valid summary of product
characteristics.

- Lack of suitability for participation in the trial, for any reason, as judged by the
Investigator (e.g. communicative disturbances (language or intellectual)).