Can the Health Benefits of a Walking-based Exercise Programme be Enhanced by Co-ingestion of a Lipid-lowering Drug?
Status:
Suspended
Trial end date:
2023-07-01
Target enrollment:
Participant gender:
Summary
Study investigates the hypothesis that an exercise programme of steady walking will have
larger effects on insulin sensitivity and glycemic control when combined with Acipimox intake
prior to each exercise session in people with pre-diabetes. Thirty-four sedentary,
overweight/obese people (aged 25-50 years, BMI >28 kg.m-2) with pre-diabetes will be
recruited using the same strategy as study 2 and split into two groups (detailed below).
Participants will undergo several pre- intervention assessments, followed by a 12-week
walking based intervention combined with either Acipimox ingestion or no drug ingestion, pre-
each exercise session. Following this, the post-assessment measures will identical to the
pre-assessment measures.
Phase:
N/A
Details
Lead Sponsor:
Liverpool John Moores University
Collaborators:
Aintree University Hospitals NHS Foundation Trust Diabetes UK Liverpool University Hospitals NHS Foundation Trust Royal Liverpool University Hospital