Can Vitamin D Reduce Heart Muscle Damage After Bypass Surgery?
Status:
Completed
Trial end date:
2019-01-21
Target enrollment:
Participant gender:
Summary
Background and study aim:
Heart diseases are among the most common causes of death worldwide. A large proportion of
deaths are caused by heart attacks (myocardial infarction), where blood flow to the heart is
reduced resulting in damage to the heart muscle. If the arteries supplying blood to the heart
start to become blocked, Coronary Artery Bypass Grafting (CABG) surgery is a treatment to
replace the blocked sections of artery can reduce angina (chest pain). However, CABG surgery
has complications, including an increased risk of heart attack. Vitamin D deficiency is
thought to be linked to poorer recovery from heart attack and CABG surgery. This study aims
to investigate if vitamin D supplementation can reduce injury to the heart following CABG
surgery.
Who can participate? Adults with vitamin D deficiency undergoing CABG
What does the study involve? Participants are randomly allocated to one of two groups. Those
in the first group receive vitamin D at 3 doses per day for 3 days before surgery. The second
group will receive a dummy pill (placebo). Both groups will have standard CABG surgery.
What are the possible benefits and risks of participating? Those in the vitamin D group might
benefit from its effects. Vitamin D has few side effects, especially when taken for only a
few days.
Where is the study run from? Shahid Modarres Hospital (Iran)
When is the study starting and how long is it expected to run for? September 2017 to January
2019
Who is funding the study? Deputy of Research of Shahid Beheshti School of Medicine
Who is the main contact? Dr Erfan Tasdighi [email protected]