Can Presumptive Anthelminthic Treatment Delay the Progression of HIV in ART-naïve Patients in Rural Africa?
Status:
Terminated
Trial end date:
2010-09-01
Target enrollment:
Participant gender:
Summary
This study focuses on one of the major health issues of Sub-Saharan Africa: multi-parasitism
and co-infections. In particular this study aims to elucidate the interaction of helminths
with HIV.
There is good reason to suspect a detrimental effect of helminth infection on the course of
HIV infection. We hypothesize, that treatment of helminths in HIV- and helminth co-infected
individuals leads to a reduction of HIV viral load. With a lower HIV RNA level one would
expect a slower decline of CD4 cells and hence also a slower progression of the disease.
Ideally this would lead to a prolongation of the chronic phase of HIV infection and to a
delay in the time when anti-retroviral treatment needs to be started.
Phase:
N/A
Details
Lead Sponsor:
Swiss Tropical & Public Health Institute
Collaborators:
Ifakara Health Research and Development Centre Merck KGaA Merck KGaA, Darmstadt, Germany University Hospital Inselspital, Berne