Overview

Can Intraosseous Antibiotics Improve the Results of Irrigation & Debridement and Prosthetic Retention for PJI?

Status:
Enrolling by invitation

Trial end date:
2024-06-01

Target enrollment:

Participant gender:

Summary

Purpose of Study: In order to improve upon the variable results seen in irrigation and debridement for periprosthetic infection, we ask if the use of intraosseous regional administration of antibiotics at the time of irrigation and debridement will improve the modest success of standard irrigation and debridement. We will use the existing literature on standard irrigation and debridement procedures to compare with the results of the irrigation and debridement with the use of intraosseous antibiotics. Impact Question: How will this study benefit the patient? Currently when an I&D fails, the patient needs to undergo two more major procedures: 1) implant removal and 2) reimplantation of the prosthesis. Any improvement in the results of a standard irrigation and debridement procedure may decrease the number of patients having to go through further extensive procedures to cure their infection.

Phase:

Phase 4

Details

Lead Sponsor:

OrthoCarolina Research Institute, Inc.

Collaborator:

American Association of Hip and Knee Surgeons

Treatments:

Anti-Bacterial Agents
Antibiotics, Antitubercular
Vancomycin