Overview

Can Additional Drug Therapy Accelerate Response Time to Antidepressants

Status:
Withdrawn

Trial end date:
1969-12-31

Target enrollment:
0

Participant gender:
All

Summary

Antidepressants are commonly prescribed and are effective for treating depression. However, they generally take 4-6 weeks for a therapeutic response. This study is evaluating whether simultaneous treatment with thyroid hormone or pindolol can decrease the response time ("getting better faster") in patients who are starting SSRI treatment.

Phase:

Phase 4

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Mark Frye

Collaborator:

University of California, Los Angeles

Treatments:

Antidepressive Agents
Citalopram
Pindolol

Criteria

Inclusion Criteria:

1. Patients, male and female, between the ages of 18 to 65

2. DSM-IV criteria for major depressive disorder

3. No prior SSRI medication treatment (if a patient has discontinued a non-SSRI
medication for side effects, they will not be excluded)

4. Ability to be followed clinically for 6 weeks

5. Each patient must understand the nature of the study and must sign an informed consent
form

Exclusion Criteria:

1. Severe suicidality (as defined by Beck Depression Inventory Question 9, responses 2 or
3)

2. Major Axis I mental illness other than major depressive disorder

3. Unstable medical health specifically cardiovascular disease, abnormal EKG, history of
severe drug allergy, poorly controlled diabetes, and asthma (pindolol
contraindication)

4. History of thyroid disease or abnormal TFT's (stage I or II)

5. Need for adjunctive antipsychotic use or additional benzodiazepine during the study

6. Pregnancy

7. Seizure disorder

8. A positive urine toxicology screen