Calcitriol, Physical Activity, and Bone Health in Cancer Survivors
Status:
Completed
Trial end date:
2018-01-01
Target enrollment:
Participant gender:
Summary
Both the calcitriol and exercise interventions are aimed at reducing fracture risk by
maintaining proper bone density, thereby preventing osteoporotic/osteopenic conditions and
increasing muscle mass. Both calcitriol and exercise are efficacious in maintaining proper
bone health and muscle mass among the general population, but little research has been done
on breast cancer patients and survivors. The combination of calcitriol and exercise, which
function through different but similar mechanisms, could produce interactive effects in
reducing fracture risk among breast cancer survivors.
Hypothesis: A combination of calcitriol along with a structured home-based walking and
progressive resistance exercise program will be efficacious in preventing bone resorption and
in increasing bone formation among survivors of invasive breast cancer.