Calcitonin Gene-related Peptide in Familial Hemiplegic Migraine (FHM) and Migraine With Aura (MA)

• Status: Completed
• Trial end date: 2008-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the present study is to explore the importance of migraine phenotype on the headache/migraine responses after CGRP in FHM-patients, MA-patients and healthy volunteers.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Danish Headache Center
• Collaborator: EUROHEAD
• Treatments: Calcitonin; Calcitonin Gene-Related Peptide

Criteria

Inclusion Criteria:

• Diagnosis of familial hemiplegic migraine (IHS-classification criteria)

• Diagnosis of migraine with aura(IHS-classification criteria)

• Healthy controls

Exclusion Criteria:

Patients and controls:

• A history of cerebrovascular disease and other CNS- disease

• A history of serious somatic and mental disease

• A history suggesting ischaemic heart disease

• A history of hypo- or hypertension

• Daily intake of medication apart from oral contraceptives

• Abuse of alcohol or medicine (opioid analgesics).

• Pregnant or breastfeeding women.

• On the study day:

• No intake of a simple analgesic in the previous 48 hours

• No headache in the previous 48 hours