Caffeine and Neurologic Recovery Following Surgery and General Anesthesia

• Status: Completed
• Trial end date: 2020-01-17
• Target enrollment: 0
• Participant gender: All

Summary

The ongoing opioid epidemic is a public health crisis, and surgical patients are particularly vulnerable to opioid-dependency and related risks. Emerging data suggest that caffeine may reduce pain after surgery. Thus, the purpose of this study is to test whether caffeine reduces pain and opioid requirements after surgery. The investigators will also test whether caffeine improves mood and brain function (e.g., learning, memory) after surgery.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Michigan
• Treatments: Caffeine; Caffeine citrate; Citric Acid; Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• Adult (>/= 18 years old) undergoing non-cardiac, non-neurologic, non-major vascular surgery requiring general anesthesia

Exclusion Criteria:

• Emergency surgery

• Cognitive impairment precluding capacity for informed consent

• Uncontrolled cardiac arrhythmias

• Seizure disorders

• Preoperative opioid use

• Diabetes

• Liver failure

• Pregnancy

• Breastfeeding

• Severe visual or auditory impairment (may hinder cognitive function testing)

• Patients unable to speak English.