CURES: The Effect of Deep Curarisation and Reversal With Sugammadex on Surgical Conditions and Perioperative Morbidity
Status:
Completed
Trial end date:
2015-01-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to investigate if a deep neuromuscular block with a continuous
infusion of rocuronium titrated to a post-tetanic count (PTC) of 1-2 responses combined with
reversal of neuromuscular blockade with sugammadex results in improved surgical conditions
for the surgeon and/or improved post-operative respiratory function for the patients as
compared to a standard technique with an intubation dose of rocuronium and top-ups as needed
to maintain a neuromuscular blockade with a train of four (TOF) count of 1-2 and reversal of
neuromuscular blockade with neostigmine/glycopyrrolate.
Furthermore, we want to investigate the effect of pneumoperitoneum, and NMB with rocuronium
and reversal with sugammadex or neostigmine/glycopyrrolate on cerebral tissue oxygenation.