CST1-Guided Oral Glucocorticoids Management for CRSwNP
Status:
Not yet recruiting
Trial end date:
2025-11-01
Target enrollment:
Participant gender:
Summary
Topical and systemic steroids constitute the first choice in medical treatment for nasal
polyps. Glucocorticoids sensitivity is significantly correlated with CST1 in nasal
secretions. The goal of this randomized, double-blind, placebo-controlled clinical trial is
to clarify the efficacy of a short course of CST1-guided oral glucocorticoids therapy for
chronic rhinosinusitis with nasal polyps. Subjects were randomized to receive either oral
glucocorticoids or oral placebo for 2 weeks. Endoscopic polyp score, Total Nasal Symptom
Score(TNSS), SNOT-22 score, Cystatin 1 and other biomarkers were evaluated before and after
the treatment. Researchers will compare oral glucocorticoids group and oral placebo group to
test CST1 predictive model of glucocorticoid therapy for Chronic Rhinosinusitis with Polyps.