Many patients with Scleroderma (Systemic sclerosis) experience damage to blood vessels,
mainly to the small arteries. A common manifestation of this is Raynaud's phenomenon (fingers
or toes turning white then blue in the cold) and digital ulcers (open sores on the
fingertips). The purpose of this study is to see how effective the study drug Human Factor
XIII Concentrate is in treating patients who have these and other common manifestation of
Scleroderma. It will be given in addition to the accepted treatments used for this disease.