COlchicine Improve EnDothElial Function in Non ST Elevation Myocardial Infarction Patients
Status:
Withdrawn
Trial end date:
2016-01-01
Target enrollment:
Participant gender:
Summary
Colchicine has antiinflammatory properties. It has been shown to be effective in improving
outcome in stable coronary disease. The exact mechanism is unclear. Study objective: to
assess the effect of colchicine on endothelial function using the EndoPAT™ in NSTEMI
Patients.
Study Hypothesis: There will be a significant difference on the RH-PAT levels of the patients
who were in treated with colchicine versus the placebo group Study design and patient
Selection One hundred and forty patients with the diagnosis of Non ST Elevation Myocardial
Infarction will be enrolled to a prospective randomized double-blind placebo controlled study
in Tel Aviv Medical Center, Tel Aviv, Israel. Patients will be recruited during their
hospitalization before cardiac catheterization. All patients will sign an informed consent.
Primary outcome will be the improvement in endothelial function between baseline and after 1
month in both groups