COX-2 Inhibitor Versus Glucocorticoid Versus Both Combined

• Status: Completed
• Trial end date: 2009-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Recent studies on molar surgery have shown that a combination of a glucocorticoid and NSAID or COX-2 selective inhibitor gives better pain relief than either of the drugs used separately. The investigators group has also shown that adding dexamethasone on top of a regimen of paracetamol, NSAID and local anesthesia resulted in 45% painfree patients at rest after ambulatory breast cancer surgery.

The goal of this study is to test the NSAID + glucocorticoid concept in ACl repair. The investigators want to evaluate whether a selective COX-2 selective inhibitor or a glucocorticoid or a combination of both drugs, as part of a multimodal analgesic regime, can provide improved pain relief and shorter hospital stay in patients undergoing outpatient ACL surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Asker & Baerum Hospital
• Treatments: BB 1101; Cyclooxygenase 2 Inhibitors; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate; Etoricoxib; Glucocorticoids; Parecoxib; Valdecoxib

Criteria

Inclusion Criteria:

• Arthroscopic reconstruction of the anterior crucial ligament (ACL)

• At least 18 years old

• ASA I + II

Exclusion Criteria:

• Known renal impairment

• Liver failure and/-or an asthmatic condition

• Pregnancy

• Breast feeding