COPE: Cannabinoids to Obviate Pain Experiment After Knee Replacement
Status:
Not yet recruiting
Trial end date:
2022-05-01
Target enrollment:
Participant gender:
Summary
Total knee replacement is a major and painful orthopaedic (joint and bone) surgery where the
knee joint is replaced with an artificial joint. It is an effective and successful procedure
to treat severe knee arthritis and reduce pain, but many patients report intense pain after
the surgery.
Postoperative pain control is predominated by opioids (morphine-based drugs). While opioids
are effective to manage the pain, they can have acute and chronic complications, including
confusion, nausea, vomiting, constipation and high risk of addiction.
Medical cannabis is an effective and safe alternative for pain treatment. Recent studies
showed that patients have reported a reduction in opioid usage when taking cannabis as a
substitute for pain relief.
This study aims to investigate whether adding medical cannabis (cannabidiol - CBD) treatment
will decrease the amount of opiates needed in the first 2 weeks after knee replacement
compared to a group given placebo.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
St. Michael's Hospital, Toronto Unity Health Toronto