COGNITIVE - Cognitive Function After Sevoflurane or Propofol Anesthesia for Open-heart Operations

• Status: Withdrawn
• Trial end date: 2015-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the study is to prove whether general anesthesia with inhaled sevoflurane reduces the frequency of neurological and cognitive impairment after open-heart operations with use of cardiopulmonary by-pass (CPB) in comparison with intravenous anesthesia with propofol.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Medical University of Gdansk
• Treatments: Anesthetics; Propofol; Sevoflurane

Criteria

Inclusion Criteria:

• adults

• valve-repair open-heart surgery without coronary artery bypass grafting

Exclusion Criteria:

• active infective endocarditis

• previous cardiac surgery

• emergency operations

• chronic renal failure (serum creatinine > 2,0 mg/dL)

• left ventricle ejection fraction < 30%

• myocardial infarction within last 30 days