CM082 Combined With Everolimus in Chinese Patients With Metastatic Renal Cell Carcinoma

• Status: Active, not recruiting
• Trial end date: 2021-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This randomized, double blind, phase 2/3 study is aimed to evaluate the efficacy and safety of CM082 in combination with everolimus in Chinese patients with advanced renal cell carcinoma. The primary endpoint is progression-free survival.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: AnewPharma
• Treatments: Everolimus; Sirolimus; Vorolanib

Criteria

Inclusion Criteria:

• Histologically or cytologically confirmed diagnosis of clear cell renal cell carcinoma

• Progressed on at least one standard therapy with VEGFR TKI

• Measurable disease per Recist v1.1

• Eastern Cooperative Group (ECOG) Performance Status score of 0 or 1

• Life expectancy of at least 12 weeks

• Adequate organ functions, and meet the following requirements:

Bone marrow: ANC ≥1.5*109/L (1500/mm3), platelet ≥100*109/L, and hemoglobin ≥9 g/dL Liver:

Total bilirubin ≤1.5 times the upper limit of normal (ULN); alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤1.5x the upper limit of normal (ULN) if no liver involvement or ≤5x the upper limit of normal with liver involvement Kidney: Creatinine ≤ 1.25 x ULN, urine protein <1+ Heart: LVEF ≥ 50%

• Willingness and ability to comply with trial and follow-up procedures

• Ability to understand the nature of this trial and give written informed consent

Exclusion Criteria:

• Currently receiving anti-cancer treatment; currently or previously have received 2 or more systemic anti-cancer treatment

• Other tumors in addition to renal cell carcinoma

• Females who are pregnant or breastfeeding

• Known hypersensitivities to CM082 or everolimus

• Those with concurrent condition(e.g. psychological, neuronal, cardiovascular, respiratory conditions or infections) that in the investigator's opinion would jeopardize compliance with the protocol

• Patients with known central nervous system (CNS) metastases

• Presence of active gastrointestinal (GI) disease or other condition that will interfere significantly with the absorption, distribution, metabolism, or excretion of CM082 or everolimus

• Any active infection

• Drug or alcohol abuser