Overview

CHildren Treated With Vincristine: A Trial Regarding Pharmacokinetics, DNA And Toxicity of Targeted Therapy In Pediatric Oncology Patients.

Status:
Recruiting

Trial end date:
2024-11-01

Target enrollment:

Participant gender:

Summary

The goal of this clinical trial is to individualize the dosage of vincristine, a chemotherapy drug, in children with cancer. The main question it aims to answer is: can vincristine dosage be optimized while carefully monitoring toxicity. The following will happen: - Participants will receive vincristine according to the institutional treatment protocol. - After receiving vincristine, blood samples will be taken at three time points. - The amount of vincristine in the blood samples will be determined. - If the amount of vincristine in the blood samples is lower than the reference and the participants do not experience toxicity due to vincristine, the dose of vincristine may be increased. - Toxicity will be carefully monitored.

Phase:

Phase 4

Details

Lead Sponsor:

Moi University

Collaborators:

Amsterdam UMC, location VUmc
Princess Maxima Center for Pediatric Oncology

Treatments:

Vincristine