CGRP's Cluster Headache Inducing Abilities in Cluster Headache Patients
Status:
Unknown status
Trial end date:
2018-12-01
Target enrollment:
Participant gender:
Summary
It has previously been shown that nitroglycerine induces cluster headache attacks in episodic
cluster headache patients (ECH patients) in bouts but not in remission phase. Furthermore,
plasma concentrations of calcitonin gene-related peptide (CGRP) have been shown to be
significantly higher during, but not before and after, an attack.
The attack appears around 20-40 min after nitroglycerine infusion with vasodilatation. During
this latency period preceding the attack, no increase in CGRP plasma concentrations is seen.
CGRP induces migraine attacks in 65% of migraine patients, and CGRP antagonists as well as
monoclonal antibodies against CGRP are effective in migraine treatment.
Based on the above the investigators hypothesize the following:
1. Provoking ECH patients in bout with CGRP triggers cluster headache attacks
2. Provoking ECH patients in remission with CGRP does not trigger cluster headache attacks
3. Provoking chronic cluster headache patients with CGRP triggers cluster headache attacks
more often than in ECH patients.