CGRP Induced Migraine Attacks in Patients With High and Low Genetic Load

• Status: Completed
• Trial end date: 2013-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators hypothesized that migraine without patients with many genetic loci associated with migraine (high genetic load) would be more sensitive and get provoked more migraine attacks by calcitonin gene-related peptide (CGRP) compared to patients with few genetic loci associated with migraine (low genetic load).

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Danish Headache Center
• Treatments: Calcitonin; Calcitonin Gene-Related Peptide; Katacalcin

Criteria

Inclusion Criteria:

• Migraine without aura patients genotyped for the 12 newly idetified gene variants associated with migraine.

Exclusion Criteria:

• Other primary headache

• A history of cerebrovascular disease and other CNS- disease

• A history suggesting ischaemic heart disease

• Serious somatic and mental disease

• Hypo- or hypertension

• Abuse of alcohol or medicine (opioid analgesics).

• Pregnant or breastfeeding women.