CEP-1 Hormonal Regulation of Circulating Endothelial Progenitor Cells and HDL-C in Men
Status:
Completed
Trial end date:
2010-05-01
Target enrollment:
Participant gender:
Summary
The original purpose of this research study was to understand the effects of testosterone (T)
and estrogen on stem cells in the blood. The knowledge would be used to help understand the
effects of T and estrogen on cardiovascular (heart and blood vessel) disease, and to help in
the development of a safe male hormonal contraceptive.
The effect of androgens on the number of circulating endothelial progenitor (CEP) cells would
best be observed in group 1 (placebo). Upon observation of group 1 under original protocol,
changes in CEP cells were not significant but there were changes in markers of inflammation,
lipids, and HDL protein composition. A modification to the protocol and title were made to
reflect this for groups 2 and 3: Hormonal regulation of HDL-C in Men.
Phase:
Phase 2
Details
Lead Sponsor:
University of Washington
Collaborator:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)