Overview

CC-486 and Venetoclax for Acute Myeloid Leukemia

Status:
Not yet recruiting
Trial end date:
2029-01-01
Target enrollment:
Participant gender:
Summary
This is an open label, dose escalation Phase I single institution pilot study for relapsed and refractory AML patients using CC-486 (oral azacitidine) with venetoclax. At the completion of dose escalation and after establishment of the MTD or recommended dose of CC-486 with venetoclax, an expansion phase will commence, using venetoclax with the MTD of CC-486 in relapsed/refractory patients.
Phase:
Phase 1
Details
Lead Sponsor:
University of Colorado, Denver
Collaborator:
Bristol-Myers Squibb
Treatments:
Cc-486
Venetoclax