Overview

CART-EGFR-IL13Ra2 in EGFR Amplified Recurrent GBM

Status:
Not yet recruiting
Trial end date:
2039-12-19
Target enrollment:
Participant gender:
Summary
This is an open-label phase 1 study to assess the safety and feasibility of autologous T cells co-expressing two CARs targeting the cryptic EGFR epitope 806 and IL13Ra2 (referred to as "CART-EGFR-IL13Ra2 cells") in patients with EGFR-amplified glioblastoma, IDH-wildtype that has recurred following prior radiotherapy.
Phase:
Phase 1
Details
Lead Sponsor:
University of Pennsylvania
Collaborator:
Tmunity Therapeutics
Treatments:
Cyclophosphamide
Fludarabine
Isotretinoin