C7R-GD2.CART Cells for Patients With Relapsed or Refractory Neuroblastoma and Other GD2 Positive Cancers (GAIL-N)
Status:
Recruiting
Trial end date:
2037-12-01
Target enrollment:
Participant gender:
Summary
This study is for patients with neuroblastoma, sarcoma, uveal melanoma, breast cancer, or
another cancer that expresses a substance on the cancer cells called GD2. The cancer has
either come back after treatment or did not respond to treatment. Because there is no
standard treatment at this time, patients are asked to volunteer in a gene transfer research
study using special immune cells called T cells. T cells are a type of white blood cell that
helps the body fight infection.
The body has different ways of fighting infection and disease. No single way seems perfect
for fighting cancers. This research study combines two different ways of fighting cancer:
antibodies and T cells. Both antibodies and T cells have been used to treat patients with
cancers. They have shown promise but have not been strong enough to cure most patients.
We have found from previous research that we can put a new gene into T cells that will make
them recognize cancer cells and kill them. In our last clinical trial we made a gene called a
chimeric antigen receptor (CAR) from an antibody that recognizes GD2, a substance found on
almost all neuroblastoma cells (GD2-CAR). We put this gene into the patients' own T cells and
gave them back to 11 neuroblastoma patients. We saw that the cells did grow for a while, but
started to disappear from the blood after 2 weeks. We think that if T cells are able to last
longer they may have a better chance of killing GD2 positive tumor cells.
Therefore, in this study we will add a new gene to the GD2 T cells that can cause the cells
to live longer. T cells need substances called cytokines to survive and the cells may not get
enough cytokines after infusion. We have added the gene C7R that gives the cells a constant
supply of cytokine and helps them to survive for a longer period of time.
In other studies using T cells, investigators found that giving chemotherapy before the T
cell infusion can improve the amount of time the T cells stay in the body and therefore the
effect the T cells can have. This is called lymphodepletion and we think that it will allow
the T cells to expand and stay longer in the body, and potentially kill cancer cells more
effectively.
The GD2-C7R T cells are an investigational product not approved by the Food and Drug
Administration.
The purpose of this study is to find the largest safe dose of GD2-C7R T cells, and also to
evaluate how long they can be detected in the blood and what affect they have on cancer.
Phase:
Phase 1
Details
Lead Sponsor:
Baylor College of Medicine
Collaborators:
Cancer Prevention Research Institute of Texas Center for Cell and Gene Therapy, Baylor College of Medicine Texas Children's Hospital The Methodist Hospital Research Institute