Burst Suppression Anesthesia for Treatment of Severe Depression

• Status: Completed
• Trial end date: 2018-09-01
• Target enrollment: 0
• Participant gender: All

Summary

This study is designed to determine if the antidepressant effects of deep anesthesia via propofol are related to EEG burst suppression.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Utah
• Treatments: Propofol

Criteria

Inclusion Criteria:

• • Diagnosis of Major Depressive Disorder (MDD) or bipolar Disorder (I or II, most recent episode must be depression

• Failed at least 2 anti-depressant treatments and no ECT in past 6 months

• Age between 18-55 years

• BMI < 35

• Hamilton Rating Scale for Depression (HSRD) score > 18

• Quick Inventory of Depression Scale (QIDS) score > 10.

Exclusion Criteria:

• • Diagnosis of primary psychotic disorder, dysthymia, or personality disorder

• Significant pre-morbid cognitive impairment

• Hypertension and current use of ACE inhibitor or AR blocker medications

• Symptomatic coronary artery disease or congestive heart failure

• History of transient ischemic or neurologic signs during the past year

• History of or susceptibility to malignant hyperthermia

• Contraindication to isoflurane or propofol anesthesia (as determined by anesthesiologist)

• Diabetes requiring insulin

• Poor kidney function

• Chronic use of benzodiazepines or opioids

• Individuals incompetent to provide consent (e.g. catatonic, psychotic).